Dimethylformamide → Hydrochloric Acid

HRID 100331Notes

Reaction equation

HRID 100331 reaction equation
[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH:28]1([C:32](=[O:33])[Cl:34])[CH2:29][CH2:30][CH2:31]1.[NH2:1][c:2]1[c:3](-[c:8]2[cH:9][cH:10][cH:11][c:12]3[cH:13][c:14]([C:17](=[O:18])[NH:19][CH:20]4[CH2:21][N:22]5[CH2:23][CH2:24][CH:25]4[CH2:26][CH2:27]5)[o:15][c:16]23)[cH:4][cH:5][cH:6][cH:7]1.[O:47]=[CH:48][N:49]([CH3:50])[CH3:51]>>[ClH:34].[NH:1]([c:2]1[c:3](-[c:8]2[cH:9][cH:10][cH:11][c:12]3[cH:13][c:14]([C:17](=[O:18])[NH:19][CH:20]4[CH2:21][N:22]5[CH2:23][CH2:24][CH:25]4[CH2:26][CH2:27]5)[o:15][c:16]23)[cH:4][cH:5][cH:6][cH:7]1)[C:32]([CH:28]1[CH2:29][CH2:30][CH2:31]1)=[O:33]

Participants

7

Reactant 5

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 78705Cyclobutanecarbonyl chlorideHCID 768006987-(2-aminophenyl)-N-(1-azabicyclo[2.2.2]octan-3-yl)-1-benzofuran-2-carboxamide

Product 2

HCID 313Hydrochloric AcidHCID 17982857HCID 17982857, compound

Sources & evidence

ORD record
ord-6da8c45c7ed64de1b61a4c502b74e5d0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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