Hydrochloric Acid → HCID 22666373, compound

HRID 1007901Notes

Reaction equation

HRID 1007901 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]([CH2:21][CH3:22])[CH2:19][CH3:20])[CH:8]=[CH:9][C:2]1=2.[ClH:23]>C(OCC)(=O)C.C(OC(C)C)(C)C>[ClH:23].[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]([CH2:19][CH3:20])[CH2:21][CH3:22])[CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22666334HCID 22666334, compound

Product 1

HCID 22666373HCID 22666373, compound

Reagents, catalysts & solvents 2

HCID 7914Diisopropyl EtherSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

In 3.0 mL of ethyl acetate is dissolved 0.62 g of N-[5-(2-benzo[b]thiophen-5-ylethoxy)pentyl]-N,N-diethylamine, to which is added 1.1 mL of 3.6 mol/L solution of dry hydrogen chloride in ethyl acetate. The mixture is stirred at ambient temperature for one hour. The reaction mixture is diluted with 5 mL of diisopropyl ether and stirred at ambient temperature for one hour. The deposited crystal is collected by filtration, washed with ethyl acetate and dried to obtain 0.55 g of N-[5-(2-benzo[b]thiophen-5-ylethoxy)pentyl]-N,N-diethylamine hydrochloride.

Workup

  1. stirringstirred at ambient temperature for one hour
  2. filtrationThe deposited crystal is collected by filtration
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-71d1bf05b5ed405e93fc4fb08bc079f5
Source dataset
uspto-grants-2004_09
Patent number
US06797726B1

Reaction notes

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