Benzyl Bromide → HCID 16657408, compound

HRID 1009179Notes

Reaction equation

HRID 1009179 reaction equation
[Cl:1][C:2]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:3]=1[CH2:4][N:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][C:6]1=[O:12].[H-].[Na+].[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CN(C=O)C>[CH2:20]([O:11][C:8]1[CH:9]=[CH:10][N:5]([CH2:4][C:3]2[CH:13]=[CH:14][C:15]([Cl:17])=[CH:16][C:2]=2[Cl:1])[C:6](=[O:12])[CH:7]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 54684476HCID 54684476, compound

Product 1

HCID 16657408HCID 16657408, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-(2,4-dichloro-benzyl)-4-hydroxy-1H-pyridin-2-one synthesized in Example 14 was dissolved in DMF followed by adding NaH and benzyl bromide to obtain 4-benzyloxy-1-(2,4-dichloro-benzyl)-1H-pyridin-2-one and the titled compound in the ratio of 1:1.

Sources & evidence

ORD record
ord-78b978a5dc8244d18a2e2bd548a24f49
Source dataset
uspto-grants-2011_07
Patent number
US07973060B2

Reaction notes

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