Ethyl cyanoacetate → 3-Hydroxybenzaldehyde

HRID 1010533Notes

Reaction equation

HRID 1010533 reaction equation
[CH2:1]([O:3][C:4](=[O:8])[CH2:5]C#[N:7])[CH3:2].[CH:9]1([C:12]([CH3:14])=[O:13])[CH2:11][CH2:10]1>>[C:4]([O-:8])(=[O:3])[CH3:5].[NH4+:7].[OH:13][C:12]1[CH:14]=[C:2]([CH:10]=[CH:11][CH:9]=1)[CH:1]=[O:3]

Participants

4

Reactant 2

HCID 7764Ethyl cyanoacetateHCID 13004Cyclopropyl methyl ketone

Product 2

HCID 1013-HydroxybenzaldehydeHCID 517165Ammonium Acetate

Procedure

Analogously to Example 1a, 750 mg of product is obtained from 5 g of ammonium acetate, 875 μl of cyanoacetic acid ethyl ester, 815 μl of cyclopropylmethylketone and 1 g of 3-hydroxybenzaldehyde.

Sources & evidence

ORD record
ord-45b050a4b7e6406f9586176aecc8ba06
Source dataset
uspto-grants-2011_07
Patent number
US07977325B2

Reaction notes

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