Dimethylformamide → HCID 14837824, compound

HRID 1030099Notes

Reaction equation

HRID 1030099 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH:13]1[CH:17]=[N:16][CH:15]=[N:14]1.CN(C)C=O.[OH-].[NH4+]>O>[N:13]1([C:2]2[C:11]3[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=3)[N:5]=[CH:4][CH:3]=2)[CH:17]=[N:16][CH:15]=[N:14]1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 68664,7-DichloroquinolineHCID 92571H-1,2,4-TriazoleHCID 14923Ammonium Hydroxide

Product 1

HCID 14837824HCID 14837824, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 1.98 g of 4,7-dichloro-quinoline, 1.38 g of 1,2,4-triazole and 10 ml of dimethyl formamide is stirred at 100° C. for 6 hours, whereupon the reaction mixture is poured into 100 ml of water and neutralized with 1 ml of a concentrated ammonium hydroxide solution. The precipitated product is filtered and recrystallized from ethanol. Thus 1.61 g of the desired product are obtained, yield 70%, Mp.: 169°-170° C.

Workup

  1. filtrationThe precipitated product is filtered
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-9354bc89c93740579913afba6a4e45da
Source dataset
uspto-grants-1992_04
Patent number
US05104884

Reaction notes

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