反应详情

To a solution of diethyl 2,5-dioxo-4-imidazolylphosphonate (6.00 g, 0.025 moles) in DMF (15 mL), under N2, is added K2CO3 (17.5 g, 0.127 moles) and 1-iodobutane (2.9 mL, 0.025 moles). This mixture is stirred at room temperature for 16 hours and then the mixture is filtered and the solid washed with ethyl acetate. The filtrate is concentrated in vacuo, to afford a yellow oil which is redissolved in ethyl acetate and washed with water and brine and then dried over MgSO4. Evaporation of solvents under high vacuum affords the required product as a viscous yellow oil which solidifies on standing.

1. filtrationthe mixture is filtered
2. washthe solid washed with ethyl acetate
3. concentrationThe filtrate is concentrated in vacuo
4. customto afford a yellow oil which
5. washwashed with water and brine
6. dry with materialdried over MgSO4
7. customEvaporation of solvents under high vacuum