Triethylamine → 2-(Trifluoromethyl)-5-[(trimethylsilyl)ethynyl]pyrimidine

HRID 103535Notes

Reaction equation

HRID 103535 reaction equation
[Al:25].[CH3:19][Si:20]([CH3:21])([CH3:22])[C:23]#[CH:24].[CH3:69][CH2:70][N:71]([CH2:72][CH3:73])[CH2:74][CH3:75].[Cu:26][I:27].[F:1][C:2]([F:3])([F:4])[S:5]([O:6][c:7]1[cH:8][n:9][c:10]([C:13]([F:14])([F:15])[F:16])[n:11][cH:12]1)(=[O:17])=[O:18].[Pd:28]([Cl:29])[Cl:30].[c:31]1([P:32]([c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[cH:45][cH:46][cH:47][cH:48][cH:49]1.[c:50]1([P:51]([c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)[c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)[cH:64][cH:65][cH:66][cH:67][cH:68]1>>[c:7]1([C:24]#[C:23][Si:20]([CH3:19])([CH3:21])[CH3:22])[cH:8][n:9][c:10]([C:13]([F:14])([F:15])[F:16])[n:11][cH:12]1

Participants

8

Reactant 7

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 5359268AluminumHCID 866151602-(Trifluoromethyl)pyrimidin-5-yl trifluoromethanesulfonate

Product 1

HCID 673509072-(Trifluoromethyl)-5-[(trimethylsilyl)ethynyl]pyrimidine

Sources & evidence

ORD record
ord-9d1509f164f7490cb5875532ecbc4b13
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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