反应详情

A mixture of 1,3-dibenzylpyrrolidine-3-carboxylic acid (Example A28, 4.0 g, 13.5 mmol), 1,1′-carbonyldiimidazole (2.42 g, 14.9 mmol), and triethylamine (2.08 mL, 14.9 mmol) in tetrahydrofuran (100 mL) is heated at reflux for 1.5 hours. The solution is cooled, poured into NH4OH (300 mL), and stirred for 18 hours. The mixture is extracted with chloroform, the organic layer is washed with water, dried, and concentrated to afford 4.13 g of the title compound as an oil; MS El+: m/z 295 (MH+).

1. temperatureis heated
2. temperatureat reflux for 1.5 hours
3. temperatureThe solution is cooled
4. extractionThe mixture is extracted with chloroform
5. washthe organic layer is washed with water
6. customdried
7. concentrationconcentrated