Butyl bromide → 2-Butoxy-4-trifluoromethyl-benzoic acid butyl ester

HRID 1042485Notes

Reaction equation

HRID 1042485 reaction equation
[OH:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:15](Br)[CH2:16][CH2:17][CH3:18].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH2:15]([O:5][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][C:9]([C:11]([F:12])([F:13])[F:14])=[CH:10][C:2]=1[O:1][CH2:10][CH2:2][CH2:3][CH3:4])[CH2:16][CH2:17][CH3:18]

Participants

5

Reactant 3

HCID 8002Butyl bromideHCID 11430Potassium CarbonateHCID 1645782-Hydroxy-4-(trifluoromethyl)benzoic acid

Product 1

HCID 668551592-Butoxy-4-trifluoromethyl-benzoic acid butyl ester

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-Hydroxy-4-trifluoromethyl-benzoic acid (755 mg) was reacted with butylbromide (0.96 ml) and K2CO3 (1.15 g) in DMF solution as described above to yield title compound.

Sources & evidence

ORD record
ord-636ee6fd91fb4f2ea2d3e00f9f50d11f
Source dataset
uspto-grants-2013_10
Patent number
US08557872B2

Reaction notes

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