Triethylamine → HCID 26470965, compound

HRID 1043062Notes

Reaction equation

HRID 1043062 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[N:15]1([CH2:21][CH2:22][CH2:23][NH2:24])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.C(N(CC)CC)C>C1COCC1.C(OCC)(=O)C>[O:18]1[CH2:19][CH2:20][N:15]([CH2:21][CH2:22][CH2:23][NH:24][C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=2[N+:12]([O-:14])=[O:13])[CH2:16][CH2:17]1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 61055N-(3-Aminopropyl)morpholineHCID 167824874-Fluoro-3-nitrobenzenesulfonamide

Product 1

HCID 26470965HCID 26470965, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

4-Fluoro-3-nitrobenzenesulfonamide (550 mg), 3-(N-morpholinyl)-1-propylamine (1.00 g), and triethylamine (1 g) were stirred in THF (30 mL) for 24 hours. The mixture was diluted with ethyl acetate, washed with NaH2PO4 solution and brine, and dried (Na2SO4), filtered and concentrated. The product was triturated from ethyl acetate.

Workup

  1. washwashed with NaH2PO4 solution and brine
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe product was triturated from ethyl acetate

Sources & evidence

ORD record
ord-6c7099b2ab47488a9f9bb301bd594f7c
Source dataset
uspto-grants-2013_10
Patent number
US08557983B2

Reaction notes

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