反应详情

To a mixture of EXAMPLE 242B (3.0 g), bis(triphenylphosphine)palladium(II) dichloride (242 mg), CuI (66 mg) in triethylamine (30 mL) was added trimethylsilylacetylene (2.2 g). The mixture was stirred at room temperature overnight. The mixture was diluted with ethyl acetate (200 mL) and washed with aqueous NH4Cl, water, brine and dried over Na2SO4. The mixture was filtered, and the solvent was evaporated and the residue was loaded on a column and eluted with 10% ethyl acetate in hexane to give the pure product.

1. washwashed with aqueous NH4Cl, water, brine
2. dry with materialdried over Na2SO4
3. filtrationThe mixture was filtered
4. customthe solvent was evaporated
5. washeluted with 10% ethyl acetate in hexane
6. customto give the pure product