反应详情

温度

100 °C

2,5-Dichloro-4-iodopyridine (0.2 g, 0.73 mmol), 6-amino-4-methyl-2,3-dihydro-1,4-benzoxazepin-5-one (0.140 g, 0.73 mmol), palladium(II) acetate (6.56 mg, 0.03 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.025 g, 0.04 mmol) and cesium carbonate (0.476 g, 1.46 mmol) were suspended in dioxane (5 mL). The mixture was heated at 100° C. for 30 minutes in a microwave reactor and then allowed to cool to room temperature. The mixture was loaded onto an SCX column and the product eluted first with MeOH and then with a 7M solution of NH3 in MeOH. Fractions containing product were combined and evaporated. The residue was purified by chromatography on silica, eluting with a gradient of 0-5% MeOH in CH2Cl2. Fractions containing product were combined and evaporated to afford 6-[(2,5-dichloropyridin-4-yl)amino]-4-methyl-2,3-dihydro-1,4-benzoxazepin-5-one (0.118 g, 48% yield); 1H NMR spectrum: (300 MHz, DMSO) δ 3.10 (3H, s), 3.55 (2H, t), 4.34 (2H, t), 6.88-6.91 (1H, m), 7.13 (1H, s), 7.36-7.39 (1H, m), 7.50 (1H, t), 8.26 (1H, s), 9.31 (1H, s); Mass spectrum: m/z (ESI+) (M+H)+ =337.96 and 339.99 and 341.96.

1. temperatureto cool to room temperature
2. washthe product eluted first with MeOH
3. additionFractions containing product
4. customevaporated
5. customThe residue was purified by chromatography on silica
6. washeluting with a gradient of 0-5% MeOH in CH2Cl2
7. additionFractions containing product
8. customevaporated