反应详情

温度

80 °C

To a solution of 368.5 g (1.39 mol) of 2-(3-chlorophenyl)-1-(5-chloropyridin-2yl)ethanone (Example 121, Step B) in dioxane (1.5 L) at 80° C. was added DBU (207 mL, 1.39 mole, 1 eq), followed by dropwise addition of methyl acrylate (124.7 mL, 1.39 mol, 1 eq) at 80° C. The reaction was stirred at 80° C. for 1 h 30 min and then allowed to cool to ambient temperature. It was quenched with 2 M aqueous HCl solution (56.5 eq) and then basified to pH 7 with saturated aqueous NaHCO3. The aqueous layer was extracted with EtOAc (2×4 L). The combined organic layers were dried over Na2SO4, filtered and the filtrate was evaporated. Purification by flash chromatography on silica gel (eluent: 40 to 100% DCM/hexanes) provided the title compound as a yellow liquid.

1. temperatureto cool to ambient temperature
2. extractionThe aqueous layer was extracted with EtOAc (2×4 L)
3. dry with materialThe combined organic layers were dried over Na2SO4
4. filtrationfiltered
5. customthe filtrate was evaporated
6. customPurification by flash chromatography on silica gel (eluent: 40 to 100% DCM/hexanes)