反应详情

A mixture of 3-ethynyl-1-(4-methoxybenzyl)-5-(pyrrolidin-1-yl)-1H-1,2,4-triazole (115 mg, 407 μmol, Eq: 1.00), 2,7-dichloroquinoxaline (89.2 mg, 448 μmol, Eq: 1.1) and triethylamine (61.8 mg, 85.2 μl, 611 μmol, Eq: 1.5) in tetrahydrofuran (3 ml) was purged with argon, then copper (I) iodide (3.1 mg, 16.3 μmol, Eq: 0.04), bis(triphenylphosphine)palladium(II) chloride (11.4 mg, 16.3 μmol, Eq: 0.04) and triphenylphosphine (4.27 mg, 16.3 μmol, Eq: 0.04) were added, the vessel was capped and heated for 18 hours to 75° C. The crude material was applied on silica gel and purified by flash chromatography to give 7-Chloro-2-[1-(4-methoxy-benzyl)-5-pyrrolidin-1-yl-1H-[1,2,4]triazol-3-ylethynyl]-quinoxaline (89 mg, 49.1%) as yellow solid. MS: m/z=445.4 (M+H+)

1. customwas purged with argon
2. customthe vessel was capped
3. temperatureheated for 18 hours to 75° C
4. custompurified by flash chromatography