Acetic Anhydride → HCID 69357913, compound

HRID 1064070Notes

Reaction equation

HRID 1064070 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[N:12]1[CH:17]=[CH:16][C:15]([CH:18]=O)=[CH:14][CH:13]=1.C(OC(=O)C)(=O)C.C(N(CC)CC)C>C(OCC)(=O)C.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[CH:18][C:15]2[CH:16]=[CH:17][N:12]=[CH:13][CH:14]=2)[C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1

Participants

7

Reactant 4

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 133894-PyridinecarboxaldehydeHCID 15880(4-Chlorophenyl)acetic acid

Product 1

HCID 69357913HCID 69357913, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
120 °C

Procedure

To mixture of (4-Chloro-phenyl)-acetic acid 9.78 g and pyridine-4-carbaldehyde 6.14 g was added acetic anhydride 20 mL and triethyl amine 20 mL. The reaction mixture was heated to 120° C. for 24 hours and cooled down to room temperature. Water and ethyl acetate were added. The solids formed was filtered, washed with water and ethyl acetate and dried to afford the title compound as a light yellow solid. MS (ES+): 260 (M+H)+.

Workup

  1. temperaturecooled down to room temperature
  2. customThe solids formed
  3. filtrationwas filtered
  4. washwashed with water and ethyl acetate
  5. customdried

Sources & evidence

ORD record
ord-b40728c1bd5b4f7da6ddb5bf40eda83e
Source dataset
uspto-grants-2005_11
Patent number
US06967254B2

Reaction notes

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