反应详情

To a mixture of 4-(2-methylbenzyl)-isonipecotic acid methyl ester hydrochloride (72 mg, 0.25 mmol), and 2-{1-(triphenylmethyl)-1H-imidazol-4-yl}-2-(4-cyanobenzyl)-acetic acid(123 mg, 0.25 mmol), HOOBT (42 mg, 0.25 mmol) and triethylamine (0.088 ml, 0.636 mmol) in DMF (3 ml), was added EDC (54 mg, 0.25 mmol) and the reaction stirred at room temperature for 18 hrs. The reaction was diluted with EtOAc and washed with saturated NaHCO3 solution, the organic extracts were dried (Na2SO4), and the solvent evaporated in vacuo. The residue was purified by chromatography(SiO2, gradient elution, 1-5% MeOH in CH2Cl2) to afford the product.

1. washwashed with saturated NaHCO3 solution
2. dry with materialthe organic extracts were dried (Na2SO4)
3. customthe solvent evaporated in vacuo
4. customThe residue was purified by chromatography(SiO2, gradient elution, 1-5% MeOH in CH2Cl2)
5. customto afford the product