反应详情

136 mg of 80% sodium hydride in oil are added to a solution of 8 g (16mmol) of benzyl 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthoate in 100 ml of DMF. The mixture is left stirring for 1 h and 1.6 ml (16.4 mmol) of methyl bromoacetate are added. The reaction mixture is left stirring overnight, and it is then poured into ice cold water and acidified to pH 2 with concentrated HCl. The solid is filtered and recrystallized from ether. 8.52 g (95%) of the expected derivative are recovered, which derivative melts at 183° C.

1. waitThe mixture is left
2. waitThe reaction mixture is left
3. stirringstirring overnight
4. additionit is then poured into ice cold water
5. filtrationThe solid is filtered
6. customrecrystallized from ether
7. custom8.52 g (95%) of the expected derivative are recovered