反应详情

To a solution of dry diisopropylamine (2.6 mL, 19.1 mM) in dry tetrahydrofuran (350 mL) at -78° C., was added dropwise a 2.5M solution of n-butyllithium in hexane (7.6 mL, 19.1 mM). After the reaction solution was stirred for 15 minutes, a solution of 2,2,5-trimethyl-3(2H)-furanone (20 g, 15.9 mM) in tetrahydrofuran (25 mL) was added dropwise. Hexamethylphosphoramide (6.4 mL, 35.7 mM) was then added after 30 minutes. Finally, 4-pyridinecarboxaldehyde (2.5 g, 23.5 mM) in tetrahydrofuran (25 mL) was added in one portion. The reaction solution was stirred 15 minutes when trifluoroacetic anhydride (6.7 mL, 47.7 mM) was added in one portion. Again, the reaction solution was stirred 15 minutes before triethylamine (11 mL, 80 mM) was added and was allowed to warm to room temperature. The reaction mixture was concentrated to 100 mL then diluted with diethyl ether (300 mL). The organic layer was extracted with 1N aqueous hydrochloric acid (100 mL). The acid layer was neutralized with solid sodium bicarbonate and washed with diethyl ether (2×100 mL). The combined etheral layers were washed with saturated aqueous sodium chloride (2×50 mL), dried over MgSO 4, filtered and concentrated under reduced pressure to give a brown crystalline solid. The crude product was purified by chromatography (silica gel, pet. ether/ethyl acetate) to afford a yellow crystalline solid (935 mg, 32% yield), m.p. 94°-96° C.

1. additionwas added in one portion
2. additionwas added
3. concentrationThe reaction mixture was concentrated to 100 mL
4. additionthen diluted with diethyl ether (300 mL)
5. extractionThe organic layer was extracted with 1N aqueous hydrochloric acid (100 mL)
6. washwashed with diethyl ether (2×100 mL)
7. washThe combined etheral layers were washed with saturated aqueous sodium chloride (2×50 mL)
8. dry with materialdried over MgSO 4
9. filtrationfiltered
10. concentrationconcentrated under reduced pressure
11. customto give a brown crystalline solid
12. customThe crude product was purified by chromatography (silica gel, pet. ether/ethyl acetate)