Pyrazole → HCID 15672112, compound

HRID 1086757Notes

Reaction equation

HRID 1086757 reaction equation
[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[C:16]([S:18](Cl)(=[O:20])=[O:19])[C:15]([Cl:22])=[CH:14][C:13]=2[Cl:23])=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:10])[F:9].CN.[NH:26]1[CH:30]=CC=N1.C(OCC)(=O)C>O1CCCC1>[Cl:1][C:2]1[C:3]([C:12]2[C:13]([Cl:23])=[CH:14][C:15]([Cl:22])=[C:16]([S:18]([NH:26][CH3:30])(=[O:20])=[O:19])[CH:17]=2)=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:10])[F:9]

Participants

6

Reactant 4

HCID 1048PyrazoleHCID 6329Methylamine2×HCID 8857Ethyl AcetateHCID 15030576HCID 15030576, compound

Product 1

HCID 15672112HCID 15672112, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 4-chloro-3-(5-chlorosulfonyl-2,4-dichlorophenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole (0.43 g, 1 mmole) in 2 ml tetrahydrofuran was added dropwise to a 40% aqueous methylamine solution dissolved in 20 ml tetrahydrofuran to react the pyrazole derivative with methylamine. After the addition was finished, the reaction was continued further for 30 minutes at room temperature. Then ethyl acetate was added to the reaction product solution to extract the objective product. The extract solution was washed with water, dehydrated, and evaporated to dryness, giving the title compound (0.42 g) in paste form, yield 100%.

Workup

  1. additionAfter the addition
  2. extractionto extract the objective product
  3. washThe extract solution was washed with water
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-a3e9ac1b31314f33a865c702891eb844
Source dataset
uspto-grants-1991_07
Patent number
US05032165

Reaction notes

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