反应详情

To 5.12 g of 60% NaH in 130 ml of THF and 30 ml of DMF was added 12.9 of 3-(2-hydroxyethyl)oxazolidin-2-one and the contents were refluxed for 2 hours. 17 g of 1-bromooctane was added and the reaction mixture was refluxed overnight. It was cooled, poured into water and extracted with ether. The combined organic extracts were dried, concentrated and the residue Was kugelrohr distilled (150°-155° C./0.5 mm) to give 16.87 g (79.6%) of an oil.

1. temperaturethe contents were refluxed for 2 hours
2. temperaturethe reaction mixture was refluxed overnight
3. temperatureIt was cooled
4. extractionextracted with ether
5. customThe combined organic extracts were dried
6. concentrationconcentrated
7. distillationdistilled (150°-155° C./0.5 mm)