1-Pyrrolidineethanamine → HCID 14763444, compound

HRID 1087818Notes

Reaction equation

HRID 1087818 reaction equation
CN(C)C[CH2:4][CH2:5][NH:6][C:7]([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)=[O:8].C(N1C=CN=C1)(N1C=CN=C1)=O.NCC[N:37]1[CH2:41][CH2:40][CH2:39][CH2:38]1.C1(N2CCNCC2)C=CC=CC=1>O1CCCC1>[C:15]1([N:12]2[CH2:11][CH2:10][N:9]([C:7]([NH:6][CH2:5][CH2:4][N:37]3[CH2:41][CH2:40][CH2:39][CH2:38]3)=[O:8])[CH2:14][CH2:13]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

6

Reactant 4

HCID 13441-PyrrolidineethanamineHCID 70961-PhenylpiperazineHCID 682631,1'-CarbonyldiimidazoleHCID 14763436HCID 14763436, compound

Product 1

HCID 14763444HCID 14763444, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 5. A mixture of 5.7 g (0.035 mole) of 1,1'-carbonyldiimidazole, 3.9 g (0.034 mole) of N-(2-aminoethyl)pyrrolidine, and 4.9 g (0.03 mole) of 1-phenylpiperazine in a total of 200 ml of tetrahydrofuran gave 5.4 g (59%) of the title compound as a white powder, m.p. 81.5°-84° C., after recrystallizing from diisopropyl ether.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-9f84d2f2ed2d4b71afa193fb8b9e4917
Source dataset
uspto-grants-1990_10
Patent number
US04960776

Reaction notes

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