Hydrochloric Acid → HCID 22163795, compound

HRID 1087828Notes

Reaction equation

HRID 1087828 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6](N1CCN(C2C=CC(F)=CC=2)CC1)=[O:7].C(N1C=CN=C1)(N1C=CN=C1)=O.CN(CCN)C.[CH3:40][O:41][C:42]1[CH:43]=[C:44]([N:52]2[CH2:57][CH2:56][NH:55][CH2:54][CH2:53]2)[CH:45]=[C:46]([O:50][CH3:51])[C:47]=1[O:48][CH3:49].[ClH:58]>O1CCCC1>[ClH:58].[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:55]1[CH2:56][CH2:57][N:52]([C:44]2[CH:43]=[C:42]([O:41][CH3:40])[C:47]([O:48][CH3:49])=[C:46]([O:50][CH3:51])[CH:45]=2)[CH2:53][CH2:54]1)=[O:7]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 66053N,N-DimethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 38387651-(3,4,5-Trimethoxyphenyl)piperazineHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

Product 1

HCID 22163795HCID 22163795, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 2.4 g (0.015 mole) of 1,1'-carbonyldiimidazole, 13 g (0.015 mole) of unsym-dimethylethylenediamine and 3.8 g (0.025 mole) of 1-(3,4,5-trimethoxyphenyl)piperazine in a total volume of 100 ml of tetrahydrofuran gave an oil as residue. The hydroxhloride was formed in ethereal hydrogen chloride and the collected solid was recrystallized from methanol-ethyl ether to yield 3.7 g (56%) of the title compound as a white solid, m.p. 205°-208° C.

Workup

  1. customThis compound was prepared
  2. customgave an oil as residue
  3. customthe collected solid was recrystallized from methanol-ethyl ether

Sources & evidence

ORD record
ord-c405756205574a05a460a1215041c101
Source dataset
uspto-grants-1990_10
Patent number
US04960776

Reaction notes

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