N,N-Dimethylethylenediamine → HCID 14763483, compound

HRID 1087833Notes

Reaction equation

HRID 1087833 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17](F)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7].C(N1C=CN=C1)(N1C=CN=C1)=O.CN(CCN)C.[N+:40](C1C=CC(N2CCNCC2)=CC=1)([O-:42])=[O:41]>O1CCCC1>[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N+:40]([O-:42])=[O:41])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7]

Participants

6

Reactant 4

HCID 66053N,N-DimethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 804471-(4-Nitrophenyl)piperazineHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

Product 1

HCID 14763483HCID 14763483, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 5.5 g (0.03 mole) of 1,1'-carbonyldiimidazole, 3.0 g (0.03 mole) of unsym-dimethylethylenediamine and 7.0 g (0.03 mole) of 1-(4-nitrophenyl)piperazine in a total volume of 200 ml of tetrahydrofuran gave an oil that solidified. The solid was recrystallized from benzene to give 5.8 g (54%) of the title compound as a yellow solid, m.p. 115°-120° C.

Workup

  1. customThis compound was prepared
  2. customgave an oil that solidified
  3. customThe solid was recrystallized from benzene

Sources & evidence

ORD record
ord-f88a0d313d0c41c9870225be9179ce23
Source dataset
uspto-grants-1990_10
Patent number
US04960776

Reaction notes

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