Hydrochloric Acid → HCID 22163781, compound

HRID 1087834Notes

Reaction equation

HRID 1087834 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17](F)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7].[F:22]C1C=C(N2CCNCC2)C=CC=1.CN(CCN)C.O1CCCC1.[ClH:46]>>[ClH:46].[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:22])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 66053N,N-DimethylethylenediamineHCID 774181-(3-Fluorophenyl)piperazineHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

Product 1

HCID 22163781HCID 22163781, compound

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 2.4 g (0.015 mole) of 1-(3-fluorophenyl)piperazine and 1.3 g (0.015 mole) of unsym-dimethyethylenediamine in a total volume of 200 ml of tetrahydrofuran gave a clear oil as residue. The hydrochloride was formed in ethereal hydrogen chloride and the collected solid was recrystallized from methanol-ethyl ether to give 2.7 g (50%) of the title compound as a white solid, m.p. 200°-203° C.

Workup

  1. customThis compound was prepared
  2. customgave a clear oil as residue

Sources & evidence

ORD record
ord-5db03516df8b4f74ba06df9c8a637ab5
Source dataset
uspto-grants-1990_10
Patent number
US04960776

Reaction notes

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