Hydrochloric Acid → HCID 22163784, compound

HRID 1087835Notes

Reaction equation

HRID 1087835 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17](F)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7].C(N1C=CN=C1)(N1C=CN=C1)=O.CN(CCN)C.[F:40]C1C=CC=CC=1N1CCNCC1.[ClH:53]>O1CCCC1>[OH2:7].[ClH:53].[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:40])[CH2:10][CH2:9]1)=[O:7]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 66053N,N-DimethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 705291-(2-Fluorophenyl)piperazineHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

Product 1

HCID 22163784HCID 22163784, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 1.5 g (0.009 mole) of 1,1'-carbonyldiimidazole, 0.8 g (0.009 mole) of unsym-dimethylethylenediamine and 1.7 g (0.009 mole) of 1-(2-fluorophenyl)piperazine in a total volume of 200 ml of tetrahydrofuran gave an oil as residue. The hydrochloride was formed in ethereal hydrogen chloride and the collected solid was recrystallized from methanol-water-ethyl ether to give the title compound as a white crystalline solid, m.p. 146°-150° C.

Workup

  1. customThis compound was prepared
  2. customgave an oil as residue

Sources & evidence

ORD record
ord-bd197d6e761940878e8c377fc7a1ea69
Source dataset
uspto-grants-1990_10
Patent number
US04960776

Reaction notes

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