N,N-Dimethylethylenediamine → HCID 14763478, compound

HRID 1087841Notes

Reaction equation

HRID 1087841 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17](F)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7].[C:22](N1C=CN=C1)([N:24]1C=CN=C1)=[O:23].CN(CCN)C.N1(C2C=CC(C(N)=O)=CC=2)CCNCC1>O1CCCC1>[NH2:24][C:22]([C:17]1[CH:18]=[CH:19][C:14]([N:11]2[CH2:12][CH2:13][N:8]([C:6]([NH:5][CH2:4][CH2:3][N:2]([CH3:21])[CH3:1])=[O:7])[CH2:9][CH2:10]2)=[CH:15][CH:16]=1)=[O:23]

Participants

6

Reactant 4

HCID 66053N,N-DimethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 111065094-(1-Piperazinyl)benzamideHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

Product 1

HCID 14763478HCID 14763478, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 3.1 g (0.019 mole) of 1,1'-carbonyldiimidazole, 1.7 g (0.019 mole) of unsym-dimethylethylenediamine and 3.9 g (0.019 mole) of 4-(1-piperazinyl)benzamide in a total volume of 150 ml of tetrahydrofuran gave a suspended white solid. The collected solid was recrystallized from ethanol-benzene to give 1.2 g (20%) of the title compound as a white solid, m.p. 193°-195° C.

Workup

  1. customThis compound was prepared
  2. customgave a suspended white solid
  3. customThe collected solid was recrystallized from ethanol-benzene

Sources & evidence

ORD record
ord-0424fb231a064f75b2d0ab0755934c9c
Source dataset
uspto-grants-1990_10
Patent number
US04960776

Reaction notes

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