1-Phenylpiperazine → HCID 14763448, compound

HRID 1087842Notes

Reaction equation

HRID 1087842 reaction equation
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[NH2:13][CH:14]1[CH2:19][CH2:18][CH2:17][N:16]([CH2:20][CH3:21])[CH2:15]1.[C:22]1([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C(OC(C)C)(C)C>O1CCCC1>[CH2:20]([N:16]1[CH2:17][CH2:18][CH2:19][CH:14]([NH:13][C:1]([N:31]2[CH2:32][CH2:33][N:28]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:29][CH2:30]2)=[O:2])[CH2:15]1)[CH3:21]

Participants

6

Reactant 4

HCID 70961-PhenylpiperazineHCID 7914Diisopropyl EtherHCID 682631,1'-CarbonyldiimidazoleHCID 980943-amino-N-ethylpiperidine

Product 1

HCID 14763448HCID 14763448, compoundYield 65.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared according to the procedure of Example 5. A mixture of 5.7 g (0.035 mole) of 1,1'-carbonyldiimidazole, 4.4 g (0.034 mole) of 3-amino-1-ethylpiperidine and 4.9 g (0.030 mole) of 1-phenylpiperazine in a total of 200 ml of tetrahydrofuran gave 6.2 g (65%) of white solid, m.p. 100°-103° C. (diisopropyl ether).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-fe2439119bef420a8941ed2295cc2285
Source dataset
uspto-grants-1990_10
Patent number
US04960776

Reaction notes

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