Hydrochloric Acid → 4-[3-(3-Trimethylgermylphenyl)-3-oxo-1-propenyl]benzoic Acid

HRID 1090430Notes

Reaction equation

HRID 1090430 reaction equation
[CH3:1][Ge:2]([CH3:13])([CH3:12])[C:3]1[CH:4]=[C:5]([C:9](=[O:11])[CH3:10])[CH:6]=[CH:7][CH:8]=1.[CH:14]([C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[CH:18][CH:17]=1)=O.Cl>C(O)(C)C.O1CCCC1.[OH-].[K+]>[CH3:13][Ge:2]([CH3:12])([CH3:1])[C:3]1[CH:4]=[C:5]([C:9](=[O:11])[CH:10]=[CH:14][C:16]2[CH:25]=[CH:24][C:19]([C:20]([OH:22])=[O:21])=[CH:18][CH:17]=2)[CH:6]=[CH:7][CH:8]=1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 15294Methyl 4-FormylbenzoateHCID 146056553'-Trimethylgermylacetophenone

Product 1

HCID 727333434-[3-(3-Trimethylgermylphenyl)-3-oxo-1-propenyl]benzoic AcidYield 23%

Reagents, catalysts & solvents 3

HCID 3776IsopropanolSolventHCID 8028TetrahydrofuranSolventHCID 14797Potassium HydroxideSolvent

Procedure

3'-Trimethylgermylacetophenone (49 mg,0.2 mmol) and methyl 4-formylbenzoate (37 mg,0.23 mmol) was dissolved in 5 ml of a mixture of 50% isopropanol and tetrahydrofuran, 1 ml of 1N aqueous potassium hydroxide solution was added, and the mixture was stirred overnight. The reaction mixture was adjusted to pH1 with 2N hydrochloric acid and extracted with AcOEt. The extract was evaporated and the residue was purified by column chromatography on silica gel (eluent: MeOH-methylene chloride) and recrystallized from a mixture of AcOEt and n-hexane to give 17 mg of pale yellow prisms, m.p.186°-188° C. (yield 22%).

Workup

  1. additionwas added
  2. extractionextracted with AcOEt
  3. customThe extract was evaporated
  4. customthe residue was purified by column chromatography on silica gel (eluent: MeOH-methylene chloride)
  5. customrecrystallized from a mixture of AcOEt and n-hexane

Sources & evidence

ORD record
ord-850aac4860b941dd91073c7024374fcf
Source dataset
uspto-grants-1992_01
Patent number
US05081271

Reaction notes

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