Water → HCID 43313256, compound

HRID 1095195Notes

Reaction equation

HRID 1095195 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1)#[N:2].C(=O)([O-])[O-].[K+].[K+].[F:16][C:17]1[C:18](F)=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH:20]=[O:21].O>CN(C=O)C>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([O:9][C:22]2[CH:23]=[CH:24][C:17]([F:16])=[CH:18][C:19]=2[CH:20]=[O:21])=[CH:5][CH:4]=1)#[N:2]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 130194-CyanophenolHCID 1376642,3-Difluorobenzaldehyde

Product 1

HCID 43313256HCID 43313256, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

To stirred solution of 4-cyanophenol (Aldrich, 5.00 g, 42 mmol) in DMF (100 mL), potassium carbonate (63 mmol) and 2-4, difluoro-benzaldehyde (Aldrich, 5.97 g, 42 mmol) were added and the mixture was stirred at 90° C. overnight. The mixture was cooled to room temperature and poured into water. The solid was filtered and dried to give a pale yellow solid. 5.2 g MS (H+), 242.

Workup

  1. additionwere added
  2. temperatureThe mixture was cooled to room temperature
  3. filtrationThe solid was filtered
  4. customdried
  5. customto give a pale yellow solid

Sources & evidence

ORD record
ord-da5e245c07f349c68718c3b01fd4fc1a
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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