Hydrochloric Acid → HCID 59395616, compound

HRID 1097715Notes

Reaction equation

HRID 1097715 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([NH:12][NH2:13])=[O:11].CCN(C(C)C)C(C)C.[Cl:23][CH2:24][CH2:25][CH2:26][C:27](Cl)=[O:28].Cl>C(Cl)Cl>[Cl:23][CH2:24][CH2:25][CH2:26][C:27]([NH:13][NH:12][C:10](=[O:11])[CH2:9][C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[Cl:1])=[O:28]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 783704-Chlorobutyryl chlorideHCID 81531DiisopropylethylamineHCID 269851332-(2-Chloro-4-fluorophenyl)acetohydrazide

Product 1

HCID 59395616HCID 59395616, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture of 2-(2-chloro-4-fluorophenyl)acetohydrazide (909 mg, 4.5 mmol) and DIPEA (0.817 ml, 4.7 mmol) in dry DCM (65 ml) was added over 20 min to 4-chlorobutyryl chloride (0.505 ml, 4.5 mmol) in dry DCM (5 ml). After 1.5 h, 2M HCl was added and the precipitated 4-chloro-N-[(2-chloro-4-fluorophenyl)acetyl]butanohydrazide was filtered off, washed with water and dried (1.24 g).

Workup

  1. filtrationthe precipitated 4-chloro-N-[(2-chloro-4-fluorophenyl)acetyl]butanohydrazide was filtered off
  2. washwashed with water
  3. customdried (1.24 g)

Sources & evidence

ORD record
ord-c3ea8023da754cdeb9b8c9789820b8ab
Source dataset
uspto-grants-2012_03
Patent number
US08143264B2

Reaction notes

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