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6-Quinolinyl trifluoromethanesulfonate → HCID 178422846, compound

HRID 1101527
Notes
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Reaction equation

HRID 1101527 reaction equation
Cc1ccc2c(cnn2C2CCCCO2)c1B1OC(C)(C)C(C)(C)O1.O=S(=O)(Oc1ccc2ncccc2c1)C(F)(F)F>CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCCCCC.CCc1cc(CC)cc(CC)c1.CCc1cccc(CC)c1.CN(C)C=O.Cc1ccccc1.O.[Li+].[Pd+2]>Cc1ccc2c(cnn2C2CCCCO2)c1-c1ccc2ncccc2c1
ParticipantsConditionsSources & evidenceReaction notes

Participants

13

Reactant 2

HCID 152903586-Quinolinyl trifluoromethanesulfonateHCID 134714813HCID 134714813, compound

Product 1

HCID 178422846HCID 178422846, compoundYield 45.26%

Reagents, catalysts & solvents 10

HCID 236647642-Propanol, 2-methyl-, lithium salt (1:1)ReagentHCID 167845palladium(II) acetateCatalystHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)CatalystHCID 962WaterSolventHCID 1140TolueneSolventHCID 6228DimethylformamideSolvent2×HCID 76021,3,5-TriethylbenzeneSolvent

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-17358b87627a40259f0d1200c9d2ac29
Source dataset
Rapid material-sparing screening of 5760 Suzuki-Miyaura coupling reactions
DOI
10.1126/science.aap9112
Original link
View source

Reaction notes

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On this pageParticipantsConditionsSources & evidenceReaction notes
HCID 8058HexaneSolvent
HCID 88641,3-DiethylbenzeneSolvent
HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard