Triethylamine → HCID 18784848, compound

HRID 1108310Notes

Reaction equation

HRID 1108310 reaction equation
Br[C:2]1[C:7]2[CH:8]=[C:9]([S:11]([CH3:14])(=[O:13])=[O:12])[O:10][C:6]=2[C:5]([O:15][CH3:16])=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(N(CC)CC)C.[O:43]1[CH2:47]CCC1.[OH2:48]>C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.Cl[Pd]Cl>[CH3:14][S:11]([C:9]1[O:10][C:6]2[C:7](=[C:2]([C:47]([OH:43])=[O:48])[CH:3]=[CH:4][C:5]=2[O:15][CH3:16])[CH:8]=1)(=[O:13])=[O:12]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 18784861HCID 18784861, compoundHCID 21881883Oxolane--water (1/1)

Product 1

HCID 18784848HCID 18784848, compound

Reagents, catalysts & solvents 1

HCID 6102075Dichlorobis(triphenylphosphine)palladiumCatalyst

Procedure

Prepared from 4-bromo-2-methanesulfonyl-7-methoxybenzofuran (1.64 g), triphenylphosphine (0.49 g), bis(triphenylphosphine)palladium (II) chloride (0.25 g) and triethylamine (7.2 ml) in tetrahydrofuran/water (68 ml/35 ml). The title compound was obtained as a white solid (1.23 g).

Sources & evidence

ORD record
ord-85061c1143524d71886f6f1652748ae3
Source dataset
uspto-grants-2000_05
Patent number
US06066657

Reaction notes

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