Hydrochloric Acid → (2-Chlorophenyl)-(3,5-dichloropyrazin-2-yl)methanol

HRID 1115913Notes

Reaction equation

HRID 1115913 reaction equation
[C:39](=[O:40])([OH:41])[O-:42].[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:6][C:7]1([CH3:8])[CH2:9][CH2:10][CH2:11][C:12]([CH3:13])([CH3:14])[NH:15]1.[Cl:16][c:17]1[n:18][c:19]([Cl:23])[cH:20][n:21][cH:22]1.[Cl:24][c:25]1[c:26]([CH:27]=[O:28])[cH:29][cH:30][cH:31][cH:32]1.[ClH:33].[Na+:43].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1>>[Cl:16][c:17]1[n:18][c:19]([Cl:23])[c:20]([CH:27]([c:26]2[c:25]([Cl:24])[cH:32][cH:31][cH:30][cH:29]2)[OH:28])[n:21][cH:22]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 69962-ChlorobenzaldehydeHCID 8028TetrahydrofuranHCID 130352,2,6,6-TetramethylpiperidineHCID 785042,6-DichloropyrazineHCID 178418339Butyllithium

Product 1

HCID 59812888(2-Chlorophenyl)-(3,5-dichloropyrazin-2-yl)methanol

Sources & evidence

ORD record
ord-cf31d477ed1d4a3e820e6e73a2dc4c33
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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