Tetrahydrofuran → 4-chloro-N-{[4-chloro-3-({3-chloro-5-[(trimethylsilyl)ethynyl]phenyl}oxy)-2-fluorophenyl]methyl}-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxamide
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([O:9][c:10]2[c:11]([F:35])[c:12]([CH2:17][NH:18][C:19](=[O:20])[c:21]3[c:22]([Cl:34])[n:23][cH:24][n:25]3[CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[cH:13][cH:14][c:15]2[Cl:16])[cH:5][c:6]([Cl:8])[cH:7]1.[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:36][Si:37]([CH3:38])([CH3:39])[C:40]#[CH:41].[Cu:47]([I:48])[I:49]>>[c:2]1([C:41]#[C:40][Si:37]([CH3:36])([CH3:38])[CH3:39])[cH:3][c:4]([O:9][c:10]2[c:11]([F:35])[c:12]([CH2:17][NH:18][C:19](=[O:20])[c:21]3[c:22]([Cl:34])[n:23][cH:24][n:25]3[CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[cH:13][cH:14][c:15]2[Cl:16])[cH:5][c:6]([Cl:8])[cH:7]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-fd508c6dbbe549cd9e0f0033a52ee5bb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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