Water → 2-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-N-pyrazin-2-yl-3-(tetrahydro-pyran-2-yl)-propionamide

HRID 1116620Notes

Reaction equation

HRID 1116620 reaction equation
[CH2:47]([Cl:48])[Cl:49].[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[c:6]([C:22]([F:23])([F:24])[F:25])[cH:7][c:8]([CH:11]([C:12](=[O:13])[OH:14])[CH2:15][CH:16]2[O:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[cH:9][cH:10]1.[CH3:56][N:57]([CH3:58])[CH:59]=[O:60].[Cl:26][C:27]([C:28]([Cl:29])=[O:30])=[O:31].[NH2:32][c:33]1[n:34][cH:35][cH:36][n:37][cH:38]1.[O:50]1[CH2:51][CH2:52][CH2:53][CH2:54]1.[OH2:55].[n:39]1[c:40]([CH3:41])[cH:42][cH:43][cH:44][c:45]1[CH3:46]>>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[c:6]([C:22]([F:23])([F:24])[F:25])[cH:7][c:8]([CH:11]([C:12](=[O:13])[NH:32][c:33]2[n:34][cH:35][cH:36][n:37][cH:38]2)[CH2:15][CH:16]2[O:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[cH:9][cH:10]1

Participants

9

Reactant 8

HCID 962WaterHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 79372,6-LutidineHCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 78747AminopyrazineHCID 21958991HCID 21958991, compound

Product 1

HCID 219589992-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-N-pyrazin-2-yl-3-(tetrahydro-pyran-2-yl)-propionamide

Sources & evidence

ORD record
ord-d2f1a475729a4ba19d74d7a41e27518b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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