Hydrochloric Acid → 6-Chloro-N-methoxy-N-methylnicotinamide

HRID 1124705Notes

Reaction equation

HRID 1124705 reaction equation
[CH3:11][N:12]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1.[CH3:27][O:28][NH:29][CH3:30].[Cl:18][C:19]([O:20][CH2:21][CH:22]([CH3:23])[CH3:24])=[O:25].[Cl:1][c:2]1[n:3][cH:4][c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10]1.[Cl:36][CH2:37][Cl:38].[ClH:26].[Na+:35].[O-:31][C:32]([OH:33])=[O:34]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([C:6](=[O:7])[N:29]([O:28][CH3:27])[CH3:30])[cH:9][cH:10]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 79724-MethylmorpholineHCID 14232N,O-DimethylhydroxylamineHCID 62365Isobutyl chloroformateHCID 792226-Chloronicotinic acid

Product 1

HCID 114355976-Chloro-N-methoxy-N-methylnicotinamide

Sources & evidence

ORD record
ord-d433fa9fd7a94ecaa200a9ea8b307682
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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