1,2-Dichloroethane → N-[1-(5-bromo-2-pyridinyl)ethyl]-2-[4-(5-methyl-1,2-oxazol-4-yl)phenyl]acetamide

HRID 1124922Notes

Reaction equation

HRID 1124922 reaction equation
[Br:18][c:19]1[cH:20][cH:21][c:22]([CH:25]([CH3:26])[NH2:27])[n:23][cH:24]1.[CH2:28]([Cl:29])[CH2:30][Cl:31].[CH3:1][c:2]1[c:3](-[c:7]2[cH:8][cH:9][c:10]([CH2:13][C:14](=[O:15])[OH:16])[cH:11][cH:12]2)[cH:4][n:5][o:6]1.[CH:32]([N:33]([CH2:34][CH3:35])[CH:36]([CH3:37])[CH3:38])([CH3:39])[CH3:40].[Cl:46][CH2:47][Cl:48].[ClH:17].[O:41]=[CH:42][N:43]([CH3:44])[CH3:45]>>[CH3:1][c:2]1[c:3](-[c:7]2[cH:8][cH:9][c:10]([CH2:13][C:14](=[O:16])[NH:27][CH:25]([c:22]3[cH:21][cH:20][c:19]([Br:18])[cH:24][n:23]3)[CH3:26])[cH:11][cH:12]2)[cH:4][n:5][o:6]1

Participants

8

Reactant 7

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 513584831-(5-Bromopyridin-2-yl)ethan-1-amineHCID 66893040[4-(5-Methylisoxazol-4-yl)phenyl]acetic acid

Product 1

HCID 91204965N-[1-(5-bromo-2-pyridinyl)ethyl]-2-[4-(5-methyl-1,2-oxazol-4-yl)phenyl]acetamide

Sources & evidence

ORD record
ord-46d6e1d1725f4a12aa8002077ec328d8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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