Triethylamine → 3-Chloro-5-(4-fluorophenylethynyl)-pyridine

HRID 1129807Notes

Reaction equation

HRID 1129807 reaction equation
[CH3:10][CH2:11][N:12]([CH2:13][CH3:14])[CH2:15][CH3:16].[CH3:32][CH2:33][O:34][C:35](=[O:36])[CH3:37].[Cl:17][c:18]1[cH:19][c:20]([O:24][S:25]([C:26]([F:27])([F:28])[F:29])(=[O:30])=[O:31])[cH:21][n:22][cH:23]1.[Cu:38][I:39].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]#[CH:9])[cH:6][cH:7]1.[Pd:40]([Cl:41])[Cl:42].[c:43]1([P:44]([c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[cH:57][cH:58][cH:59][cH:60][cH:61]1.[c:62]1([P:63]([c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[c:70]2[cH:71][cH:72][cH:73][cH:74][cH:75]2)[cH:76][cH:77][cH:78][cH:79][cH:80]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]#[C:9][c:20]2[cH:19][c:18]([Cl:17])[cH:23][n:22][cH:21]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 5226271-Ethynyl-4-fluorobenzeneHCID 151858705-Chloropyridin-3-yl trifluoromethanesulfonate

Product 1

HCID 670477483-Chloro-5-(4-fluorophenylethynyl)-pyridine

Sources & evidence

ORD record
ord-dc7e0b780f434aa5b1164c61ca518fbc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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