Hydrochloric Acid → 2-amino-N-(2-hydroxy-4-methoxy-phenyl)-5-[1-(1-methyl-4-piperidyl)pyrazol-4-yl]pyridine-3-carboxamide

HRID 1135628Notes

Reaction equation

HRID 1135628 reaction equation
[CH2:12]([N:13]([CH:14]([CH3:15])[CH3:16])[CH:17]([CH3:18])[CH3:19])[CH3:20].[CH2:52]([N:53]=[C:54]=[N:55][CH2:56][CH2:57][CH2:58][N:59]([CH3:60])[CH3:61])[CH3:62].[ClH:1].[ClH:51].[NH2:29][c:30]1[n:31][cH:32][c:33](-[c:39]2[cH:40][n:41][n:42]([CH:44]3[CH2:45][CH2:46][N:47]([CH3:50])[CH2:48][CH2:49]3)[cH:43]2)[cH:34][c:35]1[C:36](=[O:37])[OH:38].[NH2:2][c:3]1[c:4]([OH:11])[cH:5][c:6]([O:9][CH3:10])[cH:7][cH:8]1.[O:63]=[CH:64][N:65]([CH3:66])[CH3:67].[OH:21][c:22]1[cH:23][cH:24][cH:25][cH:26][n+:27]1[O-:28]>>[NH:2]([c:3]1[c:4]([OH:11])[cH:5][c:6]([O:9][CH3:10])[cH:7][cH:8]1)[C:36]([c:35]1[c:30]([NH2:29])[n:31][cH:32][c:33](-[c:39]2[cH:40][n:41][n:42]([CH:44]3[CH2:45][CH2:46][N:47]([CH3:50])[CH2:48][CH2:49]3)[cH:43]2)[cH:34]1)=[O:37]

Participants

8

Reactant 7

HCID 313Hydrochloric Acid2×HCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 81531DiisopropylethylamineHCID 99421632-Amino-5-methoxyphenolHCID 673882572-Amino-5-[1-(1-methyl-4-piperidyl)pyrazol-4-yl]pyridine-3-carboxylic acidHCID 178526252HCID 178526252, compound

Product 1

HCID 673889752-amino-N-(2-hydroxy-4-methoxy-phenyl)-5-[1-(1-methyl-4-piperidyl)pyrazol-4-yl]pyridine-3-carboxamide

Sources & evidence

ORD record
ord-1fce157741b244d696ddad54c86f63ac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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