Citric Acid → ethyl 3-{3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]-4-methylphenyl}-3-oxopropanoate

HRID 1136020Notes

Reaction equation

HRID 1136020 reaction equation
[Br:1][c:2]1[c:3](=[O:29])[n:4](-[c:19]2[cH:20][c:21]([C:22]([OH:23])=[O:24])[cH:25][cH:26][c:27]2[CH3:28])[c:5]([CH3:18])[cH:6][c:7]1[O:8][CH2:9][c:10]1[c:11]([F:17])[cH:12][c:13]([F:16])[cH:14][cH:15]1.[C:36]([CH2:37][C:38](=[O:39])[O-:40])(=[O:41])[O:42][CH2:43][CH3:44].[CH2:64]1[O:65][CH2:66][CH2:67][CH2:68]1.[CH:46]([Mg+:47])([CH3:48])[CH3:49].[Cl-:45].[Cl-:50].[Cl:30][C:31]([C:32]([Cl:33])=[O:34])=[O:35].[Cl:74][CH2:75][Cl:76].[O:69]=[CH:70][N:71]([CH3:72])[CH3:73].[OH:51][C:52]([CH2:53][C:54]([C:55](=[O:56])[OH:57])([CH2:58][C:59](=[O:60])[OH:61])[OH:62])=[O:63]>>[Br:1][c:2]1[c:3](=[O:29])[n:4](-[c:19]2[cH:20][c:21]([C:38]([CH2:37][C:36](=[O:41])[O:42][CH2:43][CH3:44])=[O:39])[cH:25][cH:26][c:27]2[CH3:28])[c:5]([CH3:18])[cH:6][c:7]1[O:8][CH2:9][c:10]1[c:11]([F:17])[cH:12][c:13]([F:16])[cH:14][cH:15]1

Participants

10

Reactant 9

HCID 311Citric AcidHCID 312Chloride2×HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 3595298Propanedioic acid, monoethyl esterHCID 220504653-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-4-methylbenzoic acidHCID 178461726HCID 178461726, compound

Product 1

HCID 22050332ethyl 3-{3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]-4-methylphenyl}-3-oxopropanoate

Sources & evidence

ORD record
ord-e91cd30354c14bd49289210cc0da40e8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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