Hydrochloric Acid → (4-{4-[5-(6-Benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

HRID 1141964Notes

Reaction equation

HRID 1141964 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([C:14](=[O:15])[OH:16])[cH:17][cH:18]1.[CH2:30]([N:31]=[C:32]=[N:33][CH2:34][CH2:35][CH2:36][N:37]([CH3:38])[CH3:39])[CH3:40].[CH2:41]([c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1)[O:48][c:49]1[cH:50][c:51]2[cH:52][cH:53][c:54](-[c:59]3[cH:60][c:61]4[n:62]([c:63]([NH:65][c:66]5[cH:67][cH:68][c:69]([NH2:72])[cH:70][cH:71]5)[n:64]3)[n:73][cH:74][cH:75]4)[cH:55][c:56]2[cH:57][cH:58]1.[CH3:81][CH2:82][N:83]([CH2:84][CH3:85])[CH2:86][CH3:87].[ClH:29].[O:76]=[CH:77][N:78]([CH3:79])[CH3:80].[OH:19][n:20]1[c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[n:27][n:28]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([C:14](=[O:16])[NH:72][c:69]2[cH:68][cH:67][c:66]([NH:65][c:63]3[n:62]4[c:61]([cH:60][c:59](-[c:54]5[cH:53][cH:52][c:51]6[cH:50][c:49]([O:48][CH2:41][c:42]7[cH:43][cH:44][cH:45][cH:46][cH:47]7)[cH:58][cH:57][c:56]6[cH:55]5)[n:64]3)[cH:75][cH:74][n:73]4)[cH:71][cH:70]2)[cH:17][cH:18]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8471TriethylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 8536054-(((tert-Butoxycarbonyl)amino)methyl)benzoic acidHCID 67318736N-[5-(6-benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-yl]-benzene-1,4-diamine

Product 1

HCID 67319336(4-{4-[5-(6-Benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-6b4c6395c0804bd2ae83d1830011bfe0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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