Hydrochloric Acid → 4-Nitrophenyl 4,4-difluoropiperidin-1-carboxylate

HRID 1143506Notes

Reaction equation

HRID 1143506 reaction equation
[CH3:10][CH2:11][N:12]([CH2:13][CH3:14])[CH2:15][CH3:16].[CH3:33][CH2:34][O:35][C:36](=[O:37])[CH3:38].[Cl:17][C:18](=[O:19])[O:20][c:21]1[cH:22][cH:23][c:24]([N+:27](=[O:28])[O-:29])[cH:25][cH:26]1.[Cl:30][CH2:31][Cl:32].[ClH:1].[F:2][C:3]1([F:9])[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1>>[F:2][C:3]1([F:9])[CH2:4][CH2:5][N:6]([C:18](=[O:19])[O:20][c:21]2[cH:22][cH:23][c:24]([N+:27](=[O:28])[O-:29])[cH:25][cH:26]2)[CH2:7][CH2:8]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 821294-Nitrophenyl chloroformateHCID 27583524,4-Difluoropiperidine

Product 1

HCID 576576134-Nitrophenyl 4,4-difluoropiperidin-1-carboxylate

Sources & evidence

ORD record
ord-1f782e11f0244dd19b6d9ed8bacb7dbb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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