Hydrochloric Acid → 6-[2-[2-(cyclopropylmethoxy)-3-methoxyphenyl]ethenyl]-N-[4-(trifluoromethyl)-1,3-thiazol-2-yl]imidazo[2,1-b][1,3]thiazole-5-carboxamide

HRID 1144476Notes

Reaction equation

HRID 1144476 reaction equation
[CH3:37][CH2:38][N:39]=[C:40]=[N:41][CH2:42][CH2:43][CH2:44][N:45]([CH3:46])[CH3:47].[CH3:49][N:50]([c:51]1[cH:52][cH:53][n:54][cH:55][cH:56]1)[CH3:57].[CH:1]1([CH2:4][O:5][c:6]2[c:7]([CH:14]=[CH:15][c:16]3[n:17][c:18]4[s:19][cH:20][cH:21][n:22]4[c:23]3[C:24](=[O:25])[OH:26])[cH:8][cH:9][cH:10][c:11]2[O:12][CH3:13])[CH2:2][CH2:3]1.[Cl:58][CH2:59][Cl:60].[ClH:48].[F:27][C:28]([c:29]1[n:30][c:31]([NH2:34])[s:32][cH:33]1)([F:35])[F:36].[O:61]=[CH:62][N:63]([CH3:64])[CH3:65]>>[CH:1]1([CH2:4][O:5][c:6]2[c:7]([CH:14]=[CH:15][c:16]3[n:17][c:18]4[s:19][cH:20][cH:21][n:22]4[c:23]3[C:24](=[O:26])[NH:34][c:31]3[n:30][c:29]([C:28]([F:27])([F:35])[F:36])[cH:33][s:32]3)[cH:8][cH:9][cH:10][c:11]2[O:12][CH3:13])[CH2:2][CH2:3]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 12014172-Thiazolamine, 4-(trifluoromethyl)-HCID 684059436-[2-[2-(Cyclopropylmethoxy)-3-methoxyphenyl]ethenyl]imidazo[2,1-b][1,3]thiazole-5-carboxylic acid

Product 1

HCID 752153096-[2-[2-(cyclopropylmethoxy)-3-methoxyphenyl]ethenyl]-N-[4-(trifluoromethyl)-1,3-thiazol-2-yl]imidazo[2,1-b][1,3]thiazole-5-carboxamide

Sources & evidence

ORD record
ord-e5dcde48cb4b4b58b9e51bf1cbe9546e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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