Acetic Acid → (2-Bromopyridin-4-yl)methanol

HRID 1147666Notes

Reaction equation

HRID 1147666 reaction equation
[Al+3:27].[Br:8][c:9]1[cH:10][c:11]([C:12](=[O:13])[OH:14])[cH:15][cH:16][n:17]1.[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[CH3:37][C:38](=[O:39])[OH:40].[Cl:18][C:19]([O:20][CH2:21][CH:22]([CH3:23])[CH3:24])=[O:25].[H-:26].[H-:29].[H-:30].[H-:31].[Li+:28]>>[Br:8][c:9]1[cH:10][c:11]([CH2:12][OH:13])[cH:15][cH:16][n:17]1

Participants

9

Reactant 8

HCID 176Acetic AcidHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 28486Lithium ionHCID 62365Isobutyl chloroformateHCID 104727Aluminum CationHCID 166653Hydride4×HCID 2227012-Bromoisonicotinic acid

Product 1

HCID 14512957(2-Bromopyridin-4-yl)methanol

Sources & evidence

ORD record
ord-63f9ca3136bf4b119e7cff385cae014e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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