Dimethylformamide → 4-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (2-vinyloxyethoxy)-amide

HRID 1150712Notes

Reaction equation

HRID 1150712 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:20])[c:5]([NH:8][c:9]2[c:10]([C:17](=[O:18])[OH:19])[cH:11][n:12]([CH3:16])[c:13](=[O:15])[cH:14]2)[cH:6][cH:7]1.[CH3:21][CH2:22][N:23]=[C:24]=[N:25][CH2:26][CH2:27][CH2:28][N:29]([CH3:30])[CH3:31].[CH3:49][CH2:50][N:51]([CH2:52][CH3:53])[CH2:54][CH3:55].[CH3:61][CH2:62][O:63][C:64]([CH3:65])=[O:66].[CH:42](=[CH2:43])[O:44][CH2:45][CH2:46][O:47][NH2:48].[O:56]=[CH:57][N:58]([CH3:59])[CH3:60].[OH:32][n:33]1[c:34]2[c:35]([cH:36][cH:37][cH:38][cH:39]2)[n:40][n:41]1>>[Br:1][c:2]1[cH:3][c:4]([F:20])[c:5]([NH:8][c:9]2[c:10]([C:17](=[O:19])[NH:48][O:47][CH2:46][CH2:45][O:44][CH:42]=[CH2:43])[cH:11][n:12]([CH3:16])[c:13](=[O:15])[cH:14]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 115809254-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acidHCID 21867017O-(2-(Vinyloxy)ethyl)hydroxylamine

Product 1

HCID 115463694-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (2-vinyloxyethoxy)-amide

Sources & evidence

ORD record
ord-53b9065e2e8d414683316e75733cbda6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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