proline dl-form → 3'-{[3-(methylsulfonyl)pyridin-2-yl]methyl}-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,1'-inden]-2'(3'H)-one

HRID 1152172Notes

Reaction equation

HRID 1152172 reaction equation
[Br:1][c:2]1[c:3]([CH2:8][CH:9]2[C:10](=[O:30])[C:11]3([CH2:12][O:13][c:14]4[cH:15][c:16]5[c:17]([cH:22][c:23]43)[O:18][CH2:19][CH2:20][O:21]5)[c:24]3[cH:25][cH:26][cH:27][cH:28][c:29]32)[n:4][cH:5][cH:6][cH:7]1.[CH3:31][S:32](=[O:33])(=[O:34])[O-:35].[CH3:46][S:47](=[O:48])[CH3:49].[CH3:50][CH2:51][O:52][C:53](=[O:54])[CH3:55].[Cu:56]([I:57])[I:58].[Na+:36].[Na:37].[OH:38][C:39]([CH:40]1[NH:41][CH2:42][CH2:43][CH2:44]1)=[O:45]>>[c:2]1([S:32]([CH3:31])(=[O:33])=[O:34])[c:3]([CH2:8][CH:9]2[C:10](=[O:30])[C:11]3([CH2:12][O:13][c:14]4[cH:15][c:16]5[c:17]([cH:22][c:23]43)[O:18][CH2:19][CH2:20][O:21]5)[c:24]3[cH:25][cH:26][cH:27][cH:28][c:29]32)[n:4][cH:5][cH:6][cH:7]1

Participants

9

Reactant 8

HCID 614proline dl-formHCID 679Dimethyl SulfoxideHCID 923Sodium ionHCID 8857Ethyl AcetateHCID 83717Copper iodideHCID 85257MethanesulfonateHCID 5360545SodiumHCID 673576033'-[(3-Bromopyridin-2-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]-benzodioxine-8,1'-inden]-2'(3'H)-one

Product 1

HCID 673565253'-{[3-(methylsulfonyl)pyridin-2-yl]methyl}-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,1'-inden]-2'(3'H)-one

Sources & evidence

ORD record
ord-70fce5051157447c8b03470bbd1fc87e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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