Dimethylformamide → N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-5-(2-fluoro-4-iodoanilino)imidazo[1,5-a]pyrazine-6-carboxamide

HRID 115617Notes

Reaction equation

HRID 115617 reaction equation
[CH3:22][C:23]1([CH3:31])[O:24][CH2:25][CH:26]([CH2:28][O:29][NH2:30])[O:27]1.[CH3:42][CH2:43][N:44]=[C:45]=[N:46][CH2:47][CH2:48][CH2:49][N:50]([CH3:51])[CH3:52].[CH3:53][N:54]1[CH2:55][CH2:56][O:57][CH2:58][CH2:59]1.[CH3:65][CH2:66][O:67][C:68](=[O:69])[CH3:70].[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:19](=[O:20])[OH:21])[n:12][cH:13][c:14]3[n:15]2[cH:16][n:17][cH:18]3)[cH:4][cH:5][c:6]([I:8])[cH:7]1.[O:60]=[CH:61][N:62]([CH3:63])[CH3:64].[OH:32][n:33]1[c:34]2[c:35]([cH:36][cH:37][cH:38][cH:39]2)[n:40][n:41]1>>[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:19](=[O:21])[NH:30][O:29][CH2:28][CH:26]3[CH2:25][O:24][C:23]([CH3:22])([CH3:31])[O:27]3)[n:12][cH:13][c:14]3[n:15]2[cH:16][n:17][cH:18]3)[cH:4][cH:5][c:6]([I:8])[cH:7]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 79724-MethylmorpholineHCID 8857Ethyl AcetateHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 10240948O-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]hydroxylamineHCID 591401265-(2-Fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyrazine-6-carboxylic acid

Product 1

HCID 72526892N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-5-(2-fluoro-4-iodoanilino)imidazo[1,5-a]pyrazine-6-carboxamide

Sources & evidence

ORD record
ord-de2198e1602e49949cab82e35b073d40
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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