反应详情

温度

100 °C

9 g of ethyl 2-(4-pyridinyl)acetate and 1.35 g of 95% NaH are mixed in 90 ml of toluene. The mixture is heated at 100° C. for 30 minutes and is then cooled, and 8.8 ml of ethyl formate are added. The mixture is left stirring at AT for 1 hour and at 100° C. for 45 minutes. The reaction medium is cooled and then 25.5 ml of 2N HCl are added. Filtration is carried out and then the precipitate formed is taken up in AcOEt and then in ether to produce 5.65 g of the expected compound.

1. temperatureis then cooled
2. waitThe mixture is left
3. temperatureThe reaction medium is cooled
4. filtrationFiltration
5. customthe precipitate formed