反应详情

4-(Benzyloxy)-2-hydroxybenzaldehyde (5.8 g), ethyl 4-bromobutyrate (7.1 mL), potassium carbonate (10.5 g) and sodium iodide (3.8 g) were added to N,N-dimethylformamide (50 mL), and the mixture was stirred overnight at room temperature. The mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water and brine and dried over magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (ethyl acetate:hexane) to give the title compound (8.2 g) as an oil.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with water and brine
3. dry with materialdried over magnesium sulfate
4. customthe solvent was evaporated
5. customThe residue was purified by silica gel column chromatography (ethyl acetate:hexane)