反应详情

To a solution of 4-hydroxy-benzonitrile (1 g, 8.395 mmol) in dimethylformamide (10 mL) were added potassium carbonate (2.321 g, 16.79 mmol) and ethyl bromoacetate (1.117 mL, 10.07 mmol), respectively. The reaction mixture was stirred at room temperature for 23 h. It was taken in ethyl acetate and diethyl ether (1:1 ratio), and the solid was filtered off. The filtrate was washed with water, brine and dried over anhydrous sodium sulfate. The solid was then filtered off, and the filtrate was concentrated in vacuo to afford ethyl (4-cyano-phenoxy)-acetate. It was used without further purification.

1. filtrationdiethyl ether (1:1 ratio), and the solid was filtered off
2. washThe filtrate was washed with water, brine
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationThe solid was then filtered off
5. concentrationthe filtrate was concentrated in vacuo